Overview Academic/Research Interest Areas

Structural information on biomolecular associations using the techniques of small-angle X-ray and neutron scattering

Chemical cross-linking with peptide analysis by MS

Selected-site mutagenesis and spectroscopy (FTIR, CD, UV-VIS)

Visualized through the use of molecular modeling

Professional Affiliations

NSF Site Review (Oct. 2002)

Structural and Molecular Biology Task Force for Oak Ridge National Lab and the Joint Institute for Neutron Science (2002 - 2005)

Elected to serve on the SHUG (Spallation neutron source, High flux isotope reactor Users Group) Executive Committee (Chair, June 2003- 2005)

Organizing/Planning committee for Neutron Scattering for Chemistry and the Chemistry/Biology Interface (NSF CHEM/Bio) Workshop (Spring to Fall 2003)

Program Advisory Panel Member for National Institute for Standards and Technology (NIST) Center for Neutron Research (NCNR) (Fall 2004 - Fall 2007)

Proposal Review Committee Member for Argonne National Laboratory's (ANL) Advanced Photon Source (APS) (Fall 2005 - Fall 2008)

Editorial Board Member for ASBMB's Journal of Biological Chemistry (Spring 2006 - Fall 2011)

Recent Projects and Results

Small-angle x-ray scattering

Model building

Supplemental Biochemical Data

Deuteration and purification of actin from Dictyostelium and small-angle neutron scattering on GA2 complex using methods of contrast variation

Recent Publications

Fengwei Bai, Terrence Town, Deepti Pradhan, Jonathan Cox, Ashish, Michel Ledizet, John F. Anderson, Richard A. Flavell, Joanna K. Krueger, Raymond A. Koski, and Erol Fikrig. (2007) "Antiviral peptides targeting the West Nile Envelope Protein" J. Virology.

Renu Garg, Ignacio J. Juncadella, Nandhini Ramamoorthi, Ashish, Shobana K. Ananthanarayanan, Venetta Thomas, Mercedes Rincon, Joanna K. Krueger, Erol Fikrig, Christopher M. Yengo and Juan Anguita. 2006. Cutting Edge: CD4 is the receptor for the tick saliva protein, Salp15. The Journal of Immunology. J. Immunology 177(10): 6579-6583.

Gautam, J.K.; Ashish; Comeau, L.D., Krueger, J.K., and Smith, M.F. Jr. (2006) Structural and Functional Evidence for the role of the TLR2 DD loop in TLR1/TLR2 Heterodimerization and Signaling. J. Biol. Chem. 281(40):30132-42.

Ashish; Garg, R.; Anguita, J.; Krueger, J.K. (2006) Binding of Full-length HIV-1 gp120 to CD4 Induces Structural Reorientation Around the gp120 Core. Biophys. J. 91(6): L69-71L.

Educational Background

B.A., Kalamazoo College

Ph.D., Princeton University

Postdoctoral (NIH/NRSA), U. T. Southwestern Medical Center at Dallas