Overview Academic/Research Interest Areas

Current work in the laboratory includes examination of S. aureus-induced cytokine expression and secretion, the use of modified S. aureus as a novel coating for bone-associated biomaterials, examination of the role of NO in the pathology of osteomyelitis, examination of the role of steroid hormones in susceptibility to S. aureus infections, and development of a novel nanoparticle-based antibiotic-delivery system to treat patients suffering from soft tissue and bone infections.

Recent Publications

Somayaji, S. N., S. Ritchie, I. Marriott, and M. C. Hudson. 2008. Staphylococcus aureus Induces RANK-L and Prostaglandin E2 Expression in Infected Murine Osteoblasts. Infect. Immun. (submitted).

Reott, M. A. Jr, S. L. Ritchie-Miller, J. Anguita, and M. C. Hudson. 2008 (On-Line 12/07). TRAIL Expression is Induced in Both Osteoblasts Containing Intracellular Staphylococcus aureus and Uninfected Osteoblasts in Infected Cultures. FEMS Microbiol. Lett. 278: 185-192.

Rabinovich, M. M., S. N Somayaji, R. R. Pillai, M. C. Hudson, K. Ellington, M. Bosse, J. Horton, and K. E. Gonsalves. 2008. Active Polymer Nanoparticles: Delivery of Antibiotics. Proceedings of the Materials Research Society (in press).

Pillai, Rajeev Raghavan, Shankari N. Somayaji, Monica Rabinovich, Michael C. Hudson, and Kenneth E. Gonsalves. 2008. Nafcillin Loaded PLGA Nanoparticles for Treatment of Osteomyelitis. J. Biomed. Mater. Res. (in press).

Ellington, J. K., M. Harris, M. C. Hudson, S. Vishin, L. X. Webb, and R. Sherertz. 2006. Intracellular Staphylococcus aureus and Antibiotic Resistance: Implications for Treatment of Staphylococcal Osteomyelitis. J. Orthop. Res. 24: 87-93.

Educational Background

B. A. in Biology, Boston University, 1982

Ph. D. in Microbiology, University of Kansas, 1987

N. I. H. Postdoctoral Fellowship, Washington University in St. Louis, 1987-1990