Donald Jacobs
Donald Jacobs
Assistant Professor, Physics & Optical Science
343 Grigg
Overview Academic/Research Interest Areas
Biophysics and Computational Biology
Constraint Theory and Network Rigidity
Modeling Protein Folding and Kinetics
Protein Design Software
Protein Stability/Flexibility Relationships
Statistical/Computational/Applied Physics
Professional Affiliations
American Physical Society
American Chemical Society
Biophysical society
Sigma Xi Scientific Research Society
Recent Publications
D.J. Jacobs (2006). Invited Review: Predicting Protein Flexibility and Stability using Network Rigidity: A new Modeling Paradigm. Recent Research Developments in Biophysics, 5:71-131.
D.R. Livesay, D.J. Jacobs, J. Kanjanapangka, Chea, H. Cortez, J. Garcia, P. Kidd, M.P. Marquez, S. Pande, D. Yang (2006). Probing the conformational dependence of calculated pKa values. Journal of Chemical Theory & Computation, 2(4):927-938.
D.J. Jacobs, D.R. Livesay, J. Hules, M.L. Tasayco (2006). Elucidating quantitative stability/flexibility relationships within thioredoxin and its fragments using a distance constraint model. Journal of Molecular Biology, 358(3):882-904.
D.R. Livesay, D.J. Jacobs (2006). Conserved quantified stability/flexibility relationships (QSFR) in an orthologous RNase H pair. Proteins: Structure, Function, & Bioinformatics, 62(1):130-143.2.
D. J. Jacobs and S. Dallakayan (2005). Elucidating Protein Thermodynamics from the Three Dimensional Structure of the Native State Using Network Rigidity. Biophysical Journal, 88:1-13.
Research Grants
D. J. Jacobs and M. F. Thorpe, Computer Implemented System for Identifying Rigid and Flexible Regions in Macromolecules, US patent # 6014449, filed February 20, (1998).
D. J. Jacobs, M. F. Thorpe and L. A. Kuhn, Floppy Inclusion and Rigid Substructure Topography (FIRST) -- beta-version of a biotechnology software partially developed at MolFlex LLC. FIRST is now being distributed from Michigan State University under Prof. Thorpe.
Educational Background
1992 Ph.D Physics, Purdue University, West Lafayette, IN
1991 M.S. Physics, Purdue University, West Lafayette, IN
1985 B.S. Physics, Union College, Schenectady, NY
1983 A.S. Engineering Science, Fulton-Montgomery Community College Johnstown
